News Release, American Heart Association
NEW ORLEANS, Sept. 5, 2019 — A study of bacteria in the gut identified differences between people with high blood pressure compared to those with high blood pressure plus depression, according to preliminary research presented at the American Heart Association’s Hypertension 2019 Scientific Sessions.
“People are ‘meta-organisms’ made up of roughly equal numbers of human cells and bacteria. Gut bacteria ecology interacts with our bodily physiology and brains, which may steer some people towards developing high blood pressure and depression,” said Bruce R. Stevens, Ph.D., lead author of the study and professor of physiology & functional genomics, medicine and psychiatry at the University of Florida College of Medicine in Gainesville, Florida. “In the future, health professionals may target your gut in order to prevent, diagnose and selectively treat different forms of high blood pressure.”
Stevens said there’s potential for this research to uncover treatment approaches that could improve outcomes in people with treatment-resistant hypertension. Nearly 20 percent of patients with high blood pressure don’t respond well to treatment, even with multiple medications.
The researchers isolated DNA (deoxyribonucleic acid, the carrier of genetic information) from gut bacteria obtained from the stool samples of 105 volunteers. They used a new technique involving artificial-intelligence software to analyze the bacteria, which revealed four distinct types of bacterial genes and signature molecules. Surprisingly, the investigators discovered unique patterns of bacteria from people with 1) high blood pressure plus depression; 2) high blood pressure without depression; 3) depression with healthy blood pressure, or 4) healthy subjects without depression or high blood pressure.
Stevens said the results suggest different medical mechanisms of high blood pressure that correlate with signature molecules produced by gut bacteria. These molecules are thought to impact the cardiovascular system, metabolism, hormones, and the nervous system.
“We believe we have uncovered new forms of high blood pressure: ‘Depressive Hypertension’ (high blood pressure with depression), which may be a completely different disease than ‘Non-Depressive Hypertension’ (high blood pressure without depression), which are each different from ‘Non-Hypertensive Depression,’” Stevens said.
Co-authors are Carl Pepine, M.D.; Mohan Raizada, Ph.D.; Kim Seungbum, Ph.D.; and Elaine Richards, Ph.D. Author disclosures are in the abstract.
The National Heart, Lung, and Blood Institute, the University of Florida Clinical and Translational Science Institute and the department of physiology & functional genomics at the University of Florida funded the study.
The Southern Maryland Chronicle is a local, small business entrusted to provide factual, unbiased reporting to the Southern Maryland Community. While we look to local businesses for advertising, we hope to keep that cost as low as possible in order to attract even the smallest of local businesses and help them get out to the public. We must also be able to pay employees(part-time and full-time), along with equipment, and website related things. We never want to make the Chronicle a “pay-wall” style news site.
To that end, we are looking to the community to offer donations. Whether it’s a one-time donation or you set up a reoccurring monthly donation. It is all appreciated. All donations at this time will be going to furthering the Chronicle through hiring individuals that have the same goals of providing fair, and unbiased news to the community. For now, donations will be going to a business PayPal account I have set-up for the Southern Maryland Chronicle, KDC Designs. All business transactions currently occur within this PayPal account. If you have any questions regarding this you can email me at firstname.lastname@example.org
Thank you for all of your support and I hope to continue bringing Southern Maryland the best news possible for a very long time. — David M. Higgins II